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Description
| Immunogen | synthetic peptide corresponding to amino acids 324-335 of the C-terminal of human presenilin-2 (PS-2). The sequence is the same in mouse and rat. |
| Specificity | Detects a C-terminal proteolytic fragment. Additional bands are observed, probably corresponding to aggregated, modified, or intact PS-2. |
| Physical form | Solution in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide. |
Properties
| antibody form | affinity isolated antibody |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 20 kDa |
| species reactivity | rat, human, mouse |
| application(s) | immunoblotting: 1-2 μg/mL using mouse or rat brain extracts |
| | immunohistochemistry (frozen sections): 2 μg/mL using 4% paraformaldehyde-fixed, frozen mouse brain tissue |
| shipped in | wet ice |
| storage temp. | 2-8°C |
Safety
References
| reference | Dewji, N.N., and Singer, S.J., Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc. Natl. Acad. Sci. U. S. A. 94, 9926-9931, (1997) Abstract |
